It's a crap shoot. Someone compared Newton to Vince Young, a valid comparison. The best thing for the Bills would be a very mobile QB. The state of our OL dictates that. I have no idea who will be #1. If Newton came out, the Bills would be reaching at #1, but unfortunately, if you want a guy, you have to do that. See Tim Tebow.
Vick would be a great option, especially if he can be had for less that 10-12 mil a year, and we can still use our #1 to fill another need, of which we obviously have plenty. Address the QB through FA by getting a proven QB. Sounds like the smart way to go.