I'm going to cheat a little and go with the 2014 home opener. CJ Spiller returned the 2nd half Kickoff for a TD and the Bill beat Miami 29 -10 to go 2 - 0.
Even more important than the result, was that it was the week the Pegulas closed on the acquisition of the Bills. After more than a decade of irrelevance on the field an Octogenerian+ owner, poor management, and real fear that the Bills were leaving Buffalo, it was great just to enjoy the game knowing our team wasn't leaving. The stadium atmosphere was electric. Although there were alot of questions about the team and coaching staff, it was a great day to squish the fish and be in first place.