In looking at the game, the best way to go at the NE Defense, especially now with the injuries, is a power running game, with some well placed play-action passing.
In the game against the Rams, NE had no fear of the running game, so they were able to flood the zones to compensate for their short-comings in the secondary. I think I even saw Phifer playing Free-Safety at one point.
If WM can get moving, they will have to keep the LB's close, and the maybe even have Harrison cheat up, leaving the young corners exposed against Moulds and Evans.
As long as the Defense continues to play well, and the Bills avoid big mistakes, they could be in line for an upset.