I don't think it would be a problem for him to learn all the blocking responsibilities of not only the Tight End position but the entire offensive line. And learn an entire NFL play book after never playing on the offensive side of the ball, which would include the route tree of his position and every other receiver, all the motion responsibilities, and be able to read defenses.
Yeah shouldn't be a big deal, after all he's the same height and weight as a Tight End.