Probably the 1992 season opener when they destroyed the LA Rams. To see that team in person was such a privilege. Such a contrast to my very first game against the Patriots in 1986. What a stinker!
On the other hand, should the Bills lose and the Pats, Jags, Chargers, and Broncos win (taken individually, these are all likely outcomes), the Bills will be looking up at a lot of teams in the standings.
Between the injuries, the rookies and newcomers, and the majority of starters not playing in the preseason, we have no idea what what we're going to see on Sunday night, do we? A little scary, but kind of exciting!