I should rephrase. If it was obvious the defense committed three blatant offside penalties where they get free, and clear shots at the QB, receivers etc, they could utilize the palpable unfair act. It's rarely used.
Example: Eagles are at the goalline and try the tush push. Before the snap, a defensive player runs straight to Hurts and knocks him back about five yards. Once that happens the second time, and it's clear the defense is doing it on purpose (doesn't have dumb players who just have a history off not saying onside), the ref could theoretically award a TD to the offense. Because the defense is clearly delaying the game and trying to intentionally injur the opposition.
If a returner was thirty yards from a clear kickoff return TD, and a player from the opposition ran from the bench to tackle him short, the rule would be enforced. The returning team gets a TD.