Absolutely. I'd like to do a comparison between this offense and Brady's 2020 Carolina offense. The Panthers struggled at QB, but they still had 4 players go for 1000+ yards of total yard from scrimmage (DJ Moore, Robbie Anderson, Curtis Samuel, and Mike Davis)
The Bills have their Robbie Anderson, Curtis Samuel (literally) and Mike Davis, but they don't have a DJ Moore. They do have a Dalton Kincaid and Khalil Shakir, who are totally different offensive weapons, so it will be interesting to see what Brady draws up in order to get similar production to what he got with that Carolina offense. And obviously, Brady has Josh Allen. And then we can't forget about Knox.
Keon can absolutely go for 1000+ in this offense, as can Cook. I'd be surprised if Samuel does, but I wouldn't be surprised with 800 yards from him. I imagine Kincaid is 900-1000 and Shakir is 700-800 but it's a real question mark.