If you watch Baltimore you quickly realize that LJ throws between the hash marks, unless forced out of the pocket. Defend the middle. They use three tight ends a lot and throw to the backs a lot. They are really not a deep threat team unless they send a TE down the middle. Keep Tre on Brown. San Francisco had a lot of success rushing to the edges rather than going up through the middle. The Ravens will have the same problem the Bills have. If you rush too deep, then JA will take off. So their four interior lineman will stay home leaving the edges open. Watching LJ run, he dekes more guys with his eyes than any QB I have seen. Watch his hips, not his eyes. Easier said than done. SF was okay letting him get his 100.
Force them to wear their white uniforms. Finding the ball against their all black uniforms make the job even harder. Stopping their RBs on first down (again easier said than done) is critical. Baltimore will go on 4th and whatever more than any team in history. Harbaugh has bought into it.
Without knowing if it is true or not, I would venture to say Baltimore is the least penalized team in the NFL. Conversely, Buffalo is good for 8-10 penalties a game. You simply can't extend Baltimore drives with stupid penalties.