None in the Fortune 500...but some not too far off....3 definitely in the top 1000:
M&T Bank is ranked 510 (Buffalo)
Moog is ranked 836 (East Aurora)
Tops is ranked 849 (Williamsville)
Rich Products is privately held, so does not make the list, but would be in the 800s
Wegmans (Rochester based) is privately held so does not make this list, but based on their expansion outside of NY, would put them in the top 500