Bob in Mich

Just a note of possible interest. There was an entire thread here the other day devoted to medical cannabis. Check it out if interested. Several postings on addiction. http://forums.twobil...ease-read-this/

Chronic users, or medical cannabis patients, do often have THC levels much higher than 5ng/ml. The number of ng/ml chosen, 5, is arbitrary and will result in capable drivers being charged. In order for the medicine to be effective for some they must maintain a therapeutic concentration higher than 5ng/ml. Really, just like many medications. Yes, I know Blackmon wasn't using medically, just sayin. Here is an interesting article on the topic http://www.mpp.org/r...i-laws-how.html

I have 417 albums. I start and play them all simultaneously each and every morning with my cup o' joe just so I can remember my roots

This study talks about THC injections bringing on paranoia. That problem was mentioned in an earlier thread on cannabis use by several posters. This is also one of the reasons patients do not seem to like using Marinol (synthetic THC) as much as the whole plant or whole plant extracts, in my opinion. I believe that the CBD lessens the anxious feelings but the researchers weren't looking at CBD in this study. Cannabinoids working in concert has been called the 'entourage effect'. Study Sheds Light on Marijuana and Paranoia By Peter Russell WebMD Health News Reviewed by Rob Hicks, MD July 17, 2014 -- An in-depth investigation has concluded that people who smoke marijuana are much more likely to have paranoia than people who don't use the drug. The study also identifies psychological factors that can lead to feelings of paranoia in people exposed to the main psychoactive ingredient in marijuana, THC. (continued at link) http://www.webmd.com...2314_hdln_2&mb= A new study suggests that a few strong whiffs of black pepper can calm anxiety brought on by marijuana How Black Pepper relieves Cannabis Anxiety By Owen Smith — 17 Jul, 2014 http://cannabisdigest.ca/black-pepper-relieves-cannabis-anxiety/ From the article While working at the Victoria Cannabis Buyers Club I was able to teach some of the members about Black Pepper. While benefiting from the medicinal effects of THC, these patients suffered from bouts with anxiety while medicating. Most patients who have tried this simply took a few sniffs of the black pepper to receive an almost immediate effect. Others have reported that after chewing on pepper corns they felt relief within an hour...

This possibility seems very exciting given the terrible rise in autism rates Medical Cannabis May Treat Autism Once thought to be the sole domain of criminals, jazz musicians, and beatniks, marijuana is coming into the mainstream as a viable treatment for a wide variety of ailments, including autism. For many, medical cannabis is now found to be a treatment that works when all others have failed. After pharmaceuticals cease working and other medically prescribed treatments come up lacking, many parents have found that plant medication is what works for their kids and family. In addition to the stunning anecdotal evidence, scientists at Stanford and UC Irvine have found that the active ingredients in cannabis, cannabinoids, are indicated in the treatment of autism-linked mutations and Fragile-X syndrome. The Stanford study found that the endocannabinoid system, which is the body’s natural cannabinoid system, was disrupted in autistics, and that marijuana helped the system correct itself. The UC Irvine study showed that once the cannabinoid system was regulated with marijuana, autistic mice improved in measures of anxiety and open-space acceptance. While neither study found that the plant medicine was a cure, the door is open to further research, giving hope to autistic patients. Continued at http://guardianlv.co...-treats-autism/ Or this article from more of a business perspective http://www.mainstreet.com/article/family/family-health/marijuana-could-treat-autism-0

I find it odd that you have no issue with nonsensical postings about McDonalds queues, breakfast cereals, Dickey Do Disease, and magical cowbells but my post, technically a response to a question on obesity with links to research studies on cannabinoids, is the one that has ruffled feathers and has become problematic. The information is contained within a single 'off topic' thread about cannabis and health problems. There is no board take over, turning every conversation to a single subject. What is inappropriate about linking to research studies on GW Pharma site? They are probably the premier cannabis research company in the world today.

My cnn link worked just fine for me http://www.cnn.com/2...etes/index.html Edit: I understand now that you mean the link within the CNN article. I had a non-cannabis article copied into my earlier post. You were correct. I had gotten carried away with my cutting and pasting and included a non-cannabis FOX article. Sorry about that and thanks for catching it. I have removed it. It was a cool picture though, eh? Gary, if the study underlying the CNN article is flawed, I will take your word for it.

Believe me when I say this, Chano. After trying to respond to your postings here, I think I would rather you have diabetes too

Funny you should ask. Check out this link from Cheerios on a new cannabis based..... ok, just kiddin, but now I can see that you are starting to come around

And this list of studies from the GW Pharmaceutical site http://www.gwpharm.com Cannabinoid Publications in Metabolic Disease The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA. Nutr Diabetes. 2013 May 27;3:e68. The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Silvestri C, Di Marzo V. Cell Metab. 2013 Apr 2;17(4):475-90. Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes Di Marzo V, Piscitelli F, Mechoulam R. Handb Exp Pharmacol. 2011;(203):75-104. Cannabinoids inhibit insulin receptor signalling in pancreatic β-cells Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Diabetes. 2011 Apr;60(4):1198-209. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans Romero-Zerbo SY, Rafacho A, Díaz-Arteaga A, Suárez J, Quesada I, Imbernon M, Ross RA, Dieguez C, Rodríguez de Fonseca F, Nogueiras R, Nadal A, Bermúdez-Silva FJ. J Endocrinol. 2011 Nov;211(2):177-85. Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle. Silvestri C, Ligresti A, Di Marzo V. Rev Endocr Metab Disord. 2011 Sep;12(3):153-62. Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. Banni S, Di Marzo V. Mol Nutr Food Res. 2010 Jan;54(1):82-92. Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Br J Pharmacol. 2009 Apr;156(7):1154-66 Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nunn AV, Bell JD, Guy GW. Nutr Metab (Lond). 2009 Apr 16;6:16. Endocannabinoids, FOXO and the metabolic syndrome: redox, function and tipping point--the view from two systems. Nunn AV, Guy GW, Bell JD. Immunobiology. 2010 Aug;215(8):617-28 The endocannabinoid system in metabolic control: a preface. Di Marzo V. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):vii-ix. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Weiss L, Zeira M, Reich S, Slavin S, Raz I, Mechoulam R, Gallily R. Neuropharmacology. 2008 Jan;54(1):244-9 Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily R. Autoimmunity. 2006 Mar;39(2):143-51.

Ask about obesity? Check out this article. Studies show that regular cannabis users are statistically less obese http://www.cnn.com/2...etes/index.html (TIME.com) -- Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar. Although marijuana has a well-deserved reputation for increasing appetite via what stoners call "the munchies," the new research, which was published in the American Journal of Medicine, is not the first to find that the drug has a two-faced relationship to weight. Three prior studies have shown that marijuana users are less likely to be obese, have a lower risk for diabetes and have lower body-mass-index measurements. And these trends occurred despite the fact that they seemed to take in more calories. (continued at the link)

These are marginal US tax rates.... today they can get as high as 39% or so, if I recall. As recent as 1986 the highest rate was 50% As recent as 1981 the highest rate was 70% As recent as 1964 the highest rate was 77% From 1949 - 1963 the highest rate was 91%

To me Trump seems to be mostly hot air, always looking for a way to push himself into the public eye. If you were the other owners, would you want to have the accompanying Donald Circus at every owners' meeting? They would need to be pretty much out of options to pick The Donald, imo

Why isn't every police-citizen encounter recorded these days? Make the recordings from the officer's vest. Make them unalterable by the police and available to any citizen that wants to file an official complaint. That by itself would discourage bullies from wanting to take the job of police officer. It would make it easier to weed out the bad apples without members of the police squad having to snitch on each other too. In many cases guilty citizens would not fight the charges in court as often if they are captured demonstrating their guilt on camera, such as DUI's.

Ask the Toronto Group to structure an ironclad, bulletproof, legal agreement not to move the team until 2035, involving ridiculous monetary penalties for doing so.. Then I will believe they won't move. About half a billion penalty would convince me.

This troll, me, has been a member on here since 2001 - about 3 years longer than you, Mr Adams. So, bite me. From my perspective you and Chano are the disruptive trolls in this thread. For God's sake, 7 posts ago (just 2 of them mine), you defended my right to post here. What happened? It is just information. Don't read the post if you aren't interested. How easy is that solution? Last I looked there were over 600 views so maybe there were readers that were interested other than you. Was it the information on pets or.....Oh, I see! You must be a pharmacy rep and didn't like that tidbit on the vicodin side-effects, was that it?

Courtesy of drugs.com Side effects of vicodin, just for comparison purposes: Some side effects of Vicodin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA. For the Consumer Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral syrup, oral tablet Along with its needed effects, acetaminophen / hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone: More common Dizziness lightheadedness Incidence not known Back, leg, or stomach pains black, tarry stools bleeding gums blood in the urine or stools blood in vomit bluish lips or skin chills choking cough or hoarseness dark urine decrease in the frequency of urination decrease in urine volume difficult or troubled breathing difficulty in passing urine (dribbling) difficulty with breathing difficulty with swallowing fast heartbeat fever fever with or without chills general body swelling general feeling of tiredness or weakness headache irregular, fast or slow, or shallow breathing light-colored stools loss of appetite lower back or side pain nausea or vomiting nosebleeds not breathing painful or difficult urination pale or blue lips, fingernails, or skin pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue severe or continuing stomach pain shortness of breath or troubled breathing skin rash, hives, or itching sore throat sore tongue sores, ulcers, or white spots on the lips or in the mouth tightness in the chest unable to speak unusual bleeding or bruising unusual tiredness or weakness upper right abdominal or stomach pain yellow eyes and skin Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone: Symptoms of overdose Bloody or cloudy urine change in consciousness chest pain or discomfort cold and clammy skin decreased awareness or responsiveness extreme drowsiness general feeling of discomfort or illness increased sweating irregular heartbeat lightheadedness, dizziness, or fainting loss of consciousness no blood pressure or pulse no muscle tone or movement not breathing severe sleepiness slow or irregular heartbeat stopping of heart sudden decrease in the amount of urine unconsciousness unpleasant breath odor Some side effects of acetaminophen / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Drowsiness relaxed and calm sleepiness Incidence not known Belching changes in mood difficulty having a bowel movement (stool) fear or nervousness feeling of indigestion hearing loss impaired hearing pain in the chest below the breastbone unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

...and get your butt kicked by a gang of baby seals.....lol

OK, if you have watched or read about cannabinoids and cannabinoid receptors, you now know that they are in animals too, including pets. After the jokes die down, if you have an older pet with health issues, it may be worth further research. Note, I am not any sort of medical professional. If your pet is tolerating its medicine well and it is effective, certainly do not change anything. At this point my non-professional opinion would be to consider this option when there isn't really much else that your vet can do. DO NOT FORCE SMOKE INTO YOUR PET'S FACE. I am talking about cannabis based medicines, such as glycerin tinctures, for pets, especially pets nearing the end of their life. Or, the concentrated oil can be smeared onto treats or even right onto the teeth of a pet that has no appetite. It will be absorbed through the tissues in the mouth as it melts. Capsules can easily be made from the concentrates if your pet can take them. Start with the tiniest of dosages and work up to an effective dose. Why would anyone do that to their pet, right? Well, as with people, it largely has to do with positive effects and lack of negative side effects. The big three positive effects I suppose are pain reduction, appetite stimulation, and restful sleep. As with people too, an animal will need a few doses to get used to the medicine and may lose some coordination with the initial doses. Be careful around stairs or drop-offs. Watch the animal until it falls asleep. If given a large dose be watchful as the pet could wet the bed. They sleep very soundly and typically wake up, go outside to do some business, come in, and head to their food bowl. I guess it shouldn't be all that surprising that veterinarians haven't started reusing it as medicine, at least the vast majority of them. Few enough doctors believe in the benefits and people are telling them directly. Not many dogs are talking, even after ingesting cannabis. I want to mention one, certain to be doubted effect that I witnessed first hand. The concentrated cannabis oil, when repeatedly applied over the course of a month or two, can shrink mast cell tumors on the skin of a dog. My dog, due to anesthesia problems could not withstand more surgery. I had read about this cannabis possibility, had the oil on hand, and so started melting my dog's leg tumor over the course of six weeks. When I returned to the same vet that had refused to remove the growth under a local, he was very surprised and wanted to know what I had done. I only took the dog to clean the wound because it now appeared that he was going to survive for a while and I was afraid that it might get infected. After cleaning up the wound area, the vet said, "the growth was now hanging on by a thread, so I removed it and sewed it up" Several months later I had to put the dog down. Eventually his problems compounded and I couldn't take watching the struggle. On his last morning before our ride to the vet however, he had a good appetite. ------------------------------------------ Here were some historical veterinary uses of cannabis http://antiquecannabisbook.com/chap14/Veterinary.htm

Some more good news. Illinois children and adults with epilepsy will soon be allowed to treat with cannabis. http://news.msn.com/...n-with-seizures Here's an 8 minute video of another recent child epilepsy success story http://www.webmd.com/news/breaking-news/marijuana-on-main-street/medical-marijuana

Chano, I never claimed to be a health care professional. I no longer care what you believe. It is clear to me that it is not worth the effort that I have put into trying to help you. You have been wasting my time Still unconvinced? I'm OK with that outcome.

Tell ya what Chano, take a deep breath and consider if you actually want anything answered or you just want to agitate. At the moment I question your sincerity. I'll start ya off on the business angle of cannabis growth and you can research from here or not. Exponential sales growth is forecast in industries that supply cannabis, process cannabis, vaporize cannabis, and a hundred different ancillary businesses that can grow up around this industry. Everyone and their brother is starting cannabis related companies and investors flocked to put money into them. They have spiked and fallen and spiked and fallen a few times. It is a pending green rush that is just waiting on the the right time. It is a sector that is driven by news and makes huge moves when it moves. Here are some of the companies in the sector. http://www.marijuanaindex.org/ Oh, I almost forgot. Here is a more recent study on cannabis and liver function. Check it out. Marijuana smoking does not appear to cause progression of liver fibrosis in the Canadian HIV/HCV Co-infection Cohort study April 2012 Authors:Brunet L, Moodie EE, Rollet K, Tyndall M, Potter M, Conway B, Walmsley S, Pick N, Cooper C, Cox J, Klein MB for the Canadian Co-infection Cohort (CTN222) Location: 21st Annual Canadian Conference on HIV/AIDS Research (CAHR 2012) Montreal Background: The literature on the effect of cannabis on liver diseases is conflicting. Cell cultures and animal model studies conclude that cannabidiol could have a therapeutic effect on liver injuries. However, cross-sectional studies of chronic HCV patients suggest that daily cannabis use is associated with fibrosis and steatosis. This study aims at estimating the causal effect of marijuana use on liver fibrosis progression in the Canadian Co-infection Cohort study. Conclusion: Marijuana smoking does not have a causal effect on progression to liver disease in co-infected individuals. http://www.ncbi.nlm....les/PMC3739469/

Just a followup in the lightening round, can't we tell something by the number of potential rounds or the allowance for magazines on these rifles? I mean unless you are hunting baby seals, why would a hunter need a hundred rounds?

Yes, there are several people here arguing against it. The truth is that there is not any strongly organized medical pot movement, at least that I know of. There are some organizations but they are weak and poorly funded. State by state, laws have been changed and seemingly citizens start anew battling the same issues over again that were battled in the last state. There is little carryover from other states. Money drives politics these days and most patients are sick or disabled and that equates to poor. Had cannabis had the power of the drug lobby behind it, we would all be smelling skunky these days. Within the last year or so, Wall Street has been taking notice of the potential and so the latest drivers in the cannabis arena are business and profit potential. Business can often blur the medical/recreational line as so many businesses do not care. This will move the country toward legalization much faster than any compassion for the sick.

You make a fine point. You can't trust things you read on the web. Be careful. Check sources. Seriously, I don't wish to argue. Look at the information, watch the video, or don't . I sincerely believe the information on cannabis use as medicine can help many people. You don't. I'm OK with that. I knew I could never convince some people, no matter the evidence