Beck Water

I haven't tried them but I have two stories to share, probably not the level of detail you'd like. But first, I want to talk to you about GMP (good manufacturing practices) and the difference between an approved generic and a compounded pharmaceutical. The manufacturing process for a drug like Ozempic has all sorts of oversight and vetting: the active ingredient is manufactured under strict regulation, there's a chain of custody with appropriate controlled storage to get the API to the site where it's manufactured into the drug, there's strict oversight of the drug manufacture and the "fill" into the final saleable form of the drug. The final formulation must be tested for potency and efficacy. The same would be true of a generic version of an FDA-approved drug. There is streamlining for approval of generic drugs, but bottom line it has to be manufactured under GMP with manufacturing controls and tests for potency and efficacy. The GLP-1RA "ozempic similars" being offered online aren't "generic ozempic". They're compounded versions of the GLP-1RA peptide. What's the difference you ask? (Well, maybe you don't ask, but you absolutely should ask) Compounding pharmacies exist in a twilight zone of regulations between state (read variable) and federal (FDA) oversight, and if they're overseas, they bypass it altogether. You might recall a case in, hmm, 2012 where a huge outbreak of fungal meningitis causing 700+ illnesses and 76 deaths was traced to a single compounding pharmacy which did not have its ***** together as far as appropriate sterile manufacturing conditions. After that, new legislation passed by congress in 2013 sought to clarify responsibility for oversight between the Feds and the States, and most states beefed up their oversight and their legal standards. However, if you click on this Pew Charitable Trust report, and scroll down to the map of states, it makes the point pretty graphically that it's still a pastiche. And if you're buying something from overseas....All bets are off. Could be just as good or better, could be trouble. "“Compounded drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs,” the FDA stated in its warning" Would I use a compounded drug? Sure: 1) we use compounded topicals 2) there's a real need for compounded drugs for patients who (for example) are allergic to the formulation of the approved drug. Compounded drugs for individual patients can literally be life-savers. 3) risk vs. benefit: if I or a family member needed a life-saving medication that was only available to us as a compounded drug, I'd go for it (I'd read up on the facilities inspection history first). Personally, if I'm injecting something into my body that is not life-saving, I want it FDA approved (Europe, EMA). Thank you for coming to my TED Talk. ******************* Story. Friend 1. Type 2 diabetic with non-alcoholic cirrhosis of the liver. In her 70s. Tried metformin, no control. Ozempic: her appetite diminished, she lost a ton of weight, she looks great, she feels great. I would guess has lost 40 lbs, 4 clothing sizes. Has been on it for years. Friend 2. Type 2 diabetic. Fought hard to avoid injectable drug for control. Metformin, something else, diet, exercise, lost weight, blood sugar still out of control. Finally went on Ozempic after threats from endocrinologist about dire consequences if she didn't. Had trouble obtaining drug due to everyone and his friend Murgatroyd taking it for weight loss. First month, miserable. Nauseous, vomiting, little appetite. After that, it eased up but she still lacks appetite and eats tiny portions slowly or she'll regret it. She has also lost a ton of weight, looks great, feels great. I would say at least 25 lbs. Been on it about 15 months. The dose for people who want to lose weight is of course lower than the diabetic dose, so there may be less risk of unpleasant side effects. I kind of know where you're at, because not having to fight my appetite and being able to lose weight without strict attention to calorie counting and exercise sounds great. But I also know there's a reason there are shortages: it's because building extra manufacturing capacity under GMP takes time. Since both my friends who are on it are diabetic, they are on it for good. But I've heard the same - people go off it and revert to their prior habits and the weight comes back.

They need the expansion pack so they can have more than 4 guys play. That's the need for the expansion set, so you can have 5 or 6 people and still play Catan. We were gifted the Seafarer's Expansion with our first set. More than 6 and it's time to break out Captain's Sonar (Now there's a game, someone ought to send Josh a set.) I don't think they just play it at camp, they play it throughout the season. The OL of the GB Packers (at Rodgers peak) was said to be seriously addicted to Catan, to the point where new additions learned very quickly that they better Get with the Program and not be futzing about with the music or other party-type stuff

Eh. I don't think we heard the same thing about Dorsey - we did hear that he tended to get worked up on the sidelines and have the "holy spirit come out of him" (Mitch Morse description) and we all saw him smashing up the booth after the Dolphins Heat Stroke loss. That's not the same thing as having a lot of energy, running from group to group teaching and coaching, and yes, getting worked up during practice But there are other differences: -As @Buffalo716 has pointed out, in 2018 when Dorsey as QB coach and Mike Shula as OC were fired after 5 years in Carolina, no one in the NFL wanted him. Shula was hired by the Giants as OC and QB coach, and it's not uncommon that the new OC brings previous assistants with him. Either Shula didn't want to bring Dorsey, or the Giants didn't want him -The Bills did confirm him as OC pretty quickly after 2022 so he was under contract, but I don't remember him getting any nibbles as a potential HC in 2022 or as a potential OC in 2021 or earlier In contrast, 41 year old Bobby Babich had a lot of off-season interest and pretty clearly would have been s n a t c h ed up as a DC elsewhere if the Bills didn't promote him. I think those differences matter more than any similarities in fiery sideline demeanor

We've heard that Babich has "a lot of energy". That typically translates to a guy who is very fiery and worked up and who might get a bit "extra" on the sideline to the detriment of calmly dialing up the next play.

How much have you seen? Because I haven't heard much about DT rotations. Functionally, it really doesn't matter if he's 2nd team or 3rd though. It's a question of we'll likely only keep 4 DTs We aren't likely to cut our 3rd round draft pick Carter (though if he totally isn't 'getting it' he might develop a lingering injury that forces him onto IR). Oliver and DaQuan Jones are locks. I haven't heard a lot about Austin Johnson, but the Bills have a $4.7M dead cap hit if they cut him because they signed him with a $1.8M bonus vs Williams, who received a $15k signing bonus and is on a VSB contract. So Johnson has to be considered ahead of Williams for that 4th slot. Functionally, Williams is fighting to stay on the team, or at least be brought into training camp. So yeah, he's trying to get noticed and make a name for himself, and sometimes that leads to trying too hard. He was out with the ACL last season. Josh commented about him being extra sweaty with the ST work he's doing so I guess he's trying.

There's hard, and then there's "Guido Torpedo" hard. There's no reason to deliver a rib-cracking hit to your own guys. Take a bit off.

I think I have a pretty good stack of receipts on this: No, I do not think they've done enough to provide weapons to Josh Allen. I think they should have been drafting WR higher long before they did.

Love how Josh holds the dog and it just relaxes and goes with it. I don't like the sound of this. In OTAs, McGovern was talking about how Josh liked the ball snapped and delivering it that way. Now Josh is changing what he's used to for McGovern? I'd like to better understand what this means. I know the QB (sometimes the center) calls protections for the OL that are appropriate for the play that's been called and what the defense is showing them. If McGovern tells Josh "No" does that mean he's rejecting the called play?

I think the question was more about, did the civil defense sirens go off (we call them "tornado sirens" here in Missouri)? Were there emergency warning text messages sent out to subscribers? Is there a gov't emergency warning text message service and do people sign up for it? As tornados go, it looks kinda mild, but I still wouldn't want to be standing on the sidewalk with the roof heading towards me.

This is Beane's last several years in a nutshell. At the time he re-signed Tre White, it looked like a no brainer and a fair deal. Then, just when it looked as though White might be himself, another serious injury. Von Miller looked like an exciting "splash" FA signing that might get us over the top. He looked the part, then bam, injury. Milano, we were thrilled to re-sign him - again, major injury. Injuries are pretty random, in my (and I think most people's) opinions and I believe White and Miller were both NCIs, Diggs is the real mystery - did his performance fall off that much? Was his behavior in the locker room toxic? Did he and Allen need a divorce? I think Beane has done pretty well with the hand he's been dealt, but he has gotten some bad hands.

This is correct

Look it up. No, regular season. 130 with Buffalo. He started a game for Chicago

I think you might have it!

However many tickets they sell, all sold

I keep telling y'all - Nathan Peterman is like Catnip for Coaches. When you put him at the whiteboard or set him watching film, he's gotta be like Stacy's Mom - he's "Got it Going On". And coaches figure that since he's got it going on between his ears, it's GOT to translate to the playing field sometime. There's probably value to having him in the QB room. Just don't count on him to play. Bears did that at the end of 2022, I will say he didn't throw an INT, but he threw like for 114 yds on 19 attempts. I looked it up. At this point, according to Spotrac, Peterman has career earnings of $7.4M, not counting his contract from the Saints. $7.4 for 7 years work. He's got 160 passing attempts, that's like $46k per pass attempt

Why are you so overly emotional and offended by the notion that people are offended? I'm exhausted by your exhaustion here, Ya Digg? In this case, seemed pretty clear that Doc was telling her to "shut up" in the humorous way it's said between work buds or friends when one brings up something that may be true, but you really don't want to think about just then or it's embarrassing or something. She wasn't disparaging Josh at all and no one was reacting to that.

I started running before work when I had my first full time job, in my early 20's. I was not at all athletic, so it was a challenge to me and I had to work up to any endurance. I came in one day, all proud of myself, and exclaimed that I'd just run 3 miles. Coworker looked at me and asked, "who was chasing you?" Josh is prevaricating, of course. He's said about his mediocre combine time "I run faster when there are guys who want to hit me chasing after me". But he's also acknowledged he "needs a little contact". Beane has said "he enjoys it, it gets him lathered up". Mitch Morse said "we're begging that ***** to slide once in a while" and "he's a little sick in the head because he likes it". So yeah, technically he's answering Kay's question correctly that he doesn't like to run for fitness or training or whatever, but make no mistake, when there are guys chasing him, he loves it.

Well, of course one question is gonna be "how well can he block?" and "can he block in-line as well as downfield?" Tall slender and 6'7 doesn't say "great blocker" to me but of course technique and want to go for a lot. You're right that Morris was not a great blocker to start with, and especially in-line. He was a converted WR and it took him a minute. He runs a pretty route though and his blocking has improved. The other question is gonna be ST. Morris has become a ST stalwart. Josh did put in a word for how Davidson is working on ST. Morris converted from being a WR to being a TE sometime during his college career, so he kind of came to the Bills sort of sketchy on the blocking, especially inline.

He did turn into a decent player for the Lions, and was signed off a couple of different practice squads to regular rosters during his rookie year after the injury bug bit (then cut again). But it was still 2 years before he took the handoff for his first NFL regular season carry To hear TBD tell it, we couldn't possibly cut him because he'd be signed immediately to another team's regular roster. He's just one example that came to mind, but it seems to me it was a regular feature fur us to be agonizing about the UDFA or late round draftees on our then-mediocre or bad team who would immediately be grabbed up and signed by other teams Yes. Yes, we have.

You are right. I just watched it 5 times.

He makes the team every year because he's exactly the football equivalent of a Swiss Army Knife. He plays ST. He can play nickel, safety, and CB. He plays none of these roles at a starting level, but then, he's not a starter. Show me a backup who plays consistently at a starter level and I'll show you a guy starting on another team.

Truth, I had forgotten that. Going for the ball instead of trying to knock it away is at least something DBs are coached to do in most circumstances. Roughing the punter, Never Ever Ever They're mixing it up, sounds like

Strange how the Bills coaches, who watch every snap, seem to think he's taking the right angle, making the tackles, and making the hits. The major miscue that gives Bills fans PTSD about him was the 2022 Vikings game where he allowed Justin Jefferson to make a 32 yd catch on 4th and 18, starting a series of miscues that led to an OT loss. It appears that he WENT FOR THE BALL to try to intercept, when he should have been playing to knock it down.