Clinical evidence suggests that schizophrenia occurs in patients with GID at rates higher than in the general population and that patients with GID may have schizophrenia-like personality traits. Conversely, patients with schizophrenia may experience alterations in gender identity and gender role perception
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274821/#:~:text=Clinical evidence suggests that schizophrenia,identity and gender role perception.
An influential model of GID, briefly alluded to above, posits that this condition is due to a disorder of sexual development which specifically involves the brain, but spares the internal and external genitalia [3]. This theory has gained some support from brain imaging studies in which sexually dimorphic brain regions resemble those of the desired rather than the anatomical gender in subjects with GID [38–40]. There is evidence that some brain structures may show a similar variation in schizophrenia, with men showing a “feminized” pattern and women showing a “masculinized” pattern [41, 42], leading to the proposal that schizophrenia itself may be related to gender-atypical brain development, perhaps caused by prenatal hormonal imbalances [43, 44].