Buffalo Bills Fan

Feel for bad President Trump friend died to covid19. People down play or over play it. Just gotta be prepared.

Just happy President Trump prepared for this. If it was a democrat or some not good other person. My biggest worry but President Trump prepared for everything. I'm happy.

Right city's don't have that or much room. Agree with this.

What worries is people get too excited with government opens.. With no social distancing. Acting like a win, should still be a caution with caution with this thing still going on.

Understand all ways. Just looking at all things.

Dr Tedros I wished didn't play favoritism. Problem would be solved way sooner.... Some people I know around here had big problems with. Reminds (people I live) me of dr tedros adhanom ghebreyesus. Favoritism. Rather than fight for real and truth. Would love to have board here replace them like in person knowing would be fun. Have a next door lady kind of like people here on PPP. We get along great.

Agree man with economy.

For me not going to make projections. Everyone seems to get it wrong. Could be or could not. Way too early to talk about July or August for covid19.

Nevermind ..

There is ACE2 receptor along with furin in heart. SARS-CoV-2 and ACE2 Angiotensin-converting enzyme 2 (ACE2) is a membrane-bound aminopeptidase that has a vital role in the cardiovascular and immune systems4. ACE2 is involved in heart function and the development of hypertension and diabetes mellitus. In addition, ACE2 has been identified as a functional receptor for coronaviruses4, including SARS-CoV and SARS-CoV-2. SARS-CoV-2 infection is triggered by binding of the spike protein of the virus to ACE2, which is highly expressed in the heart and lungs4. SARS-CoV-2 mainly invades alveolar epithelial cells, resulting in respiratory symptoms. These symptoms are more severe in patients with CVD, which might be associated with increased secretion of ACE2 in these patients compared with healthy individuals. ACE2 levels can be increased by the use of renin–angiotensin–aldosterone system inhibitors. Given that ACE2 is a functional receptor for SARS-CoV-2, the safety and potential effects of antihypertension therapy with ACE inhibitors or angiotensin-receptor blockers in patients with COVID-19 should be carefully considered. Whether patients with COVID-19 and hypertension who are taking an ACE inhibitor or angiotensin-receptor blocker should switch to another antihypertensive drug remains controversial, and further evidence is required. Acute cardiac injury Reports suggest that the Middle East respiratory syndrome-related coronavirus (MERS-CoV) can cause acute myocarditis and heart failure5. SARS-CoV-2 and MERS-CoV have similar pathogenicity, and the myocardial damage caused by infection with these viruses undoubtedly increases the difficulty and complexity of patient treatment. Myocardial injury associated with the SARS-CoV-2 occurred in 5 of the first 41 patients diagnosed with COVID-19 in Wuhan, which mainly manifested as an increase in high-sensitivity cardiac troponin I (hs-cTnI) levels (>28 pg/ml)3. In this study, four of five patients with myocardial injury were admitted to the intensive-care unit (ICU), which indicates the serious nature of the myocardial injury in patients with COVID-19. Blood-pressure levels were significantly higher in patients treated in the ICU than in those not treated in the ICU (mean systolic blood pressure 145 mmHg versus 122 mmHg; P < 0.001)3. In another report of 138 patients with COVID-19 in Wuhan, 36 patients with severe symptoms were treated in the ICU1. The levels of biomarkers of myocardial injury were significantly higher in patients treated in the ICU than in those not treated in the ICU (median creatine kinase (CK)-MB level 18 U/l versus 14 U/l, P < 0.001; hs-cTnI level 11.0 pg/ml versus 5.1 pg/ml, P = 0.004), suggesting that patients with severe symptoms often have complications involving acute myocardial injury1. In addition, among the confirmed cases of SARS-CoV-2 infection reported by the National Health Commission of China (NHC), some of the patients first went to see a doctor because of cardiovascular symptoms. The patients presented with heart palpitations and chest tightness rather than with respiratory symptoms, such as fever and cough, but were later diagnosed with COVID-19. Among the people who died from COVID-19 reported by the NHC, 11.8% of patients without underlying CVD had substantial heart damage, with elevated levels of cTnI or cardiac arrest during hospitalization. Therefore, in patients with COVID-19, the incidence of cardiovascular symptoms is high, owing to the systemic inflammatory response and immune system disorders during disease progression. The mechanism of acute myocardial injury caused by SARS-CoV-2 infection might be related to ACE2. ACE2 is widely expressed not only in the lungs but also in the cardiovascular system and, therefore, ACE2-related signalling pathways might also have a role in heart injury. Other proposed mechanisms of myocardial injury include a cytokine storm triggered by an imbalanced response by type 1 and type 2 T helper cells3,6, and respiratory dysfunction and hypoxaemia caused by COVID-19, resulting in damage to myocardial cells. Chronic cardiovascular damage A 12-year follow-up survey of 25 patients who recovered from SARS-CoV infection found that 68% had hyperlipidaemia, 44% had cardiovascular system abnormalities and 60% had glucose metabolism disorders7. https://www.nature.com/articles/s41569-020-0360-5?fbclid=IwAR3Ni4Y6EokoleVLOGkmHia8Si03IwBuGV8kRTJjUJEBGS5ULlfAOHb2gHE It's why this is so complex understand both sides. I wonder President Trump when he finds out more about the lab. Hopefully shares with everyone.

Right. But for real anything for her abortion laws in her eyes. Tried to sneak something in stimulus loop hole by supporting that crap. Nancy Pelosi very sad human.

Right agree DR.

Nevermind

Immerse Yourself in a Forest for Better Health Spending time in forests makes us healthier. Photo: Jennifer Miller Most of us sense that taking a walk in a forest is good for us. We take a break from the rush of our daily lives. We enjoy the beauty and peace of being in a natural setting. Now, research is showing that visiting a forest has real, quantifiable health benefits, both mental and physical. Even five minutes around trees or in green spaces may improve health. Think of it as a prescription with no negative side effects that's also free. Health Benefits From Forests The reference list at the bottom of this page has links to specific studies on these benefits. Exposure to forests and trees: boosts the immune system lowers blood pressure reduces stress improves mood increases ability to focus, even in children with ADHD accelerates recovery from surgery or illness increases energy level improves sleep https://www.dec.ny.gov/lands/90720.html Sorry going off topic being in forest helps immune system among other things. But still have to check out for ticks. Just trying to something a feel good post lol.

Just think it is a complex matter for everything. Things truly not that simple with this Chinese virus. But I understand everyone points. GG, Mezza and you Gal all make good points. On everyone side on points. I'm just researching here now all of the receptor's in the body. More info comes i'll share it with that..

Researchers have identified microscopic features that could make the pathogen more infectious than the SARS virus — and serve as drug targets. Smriti Mallapaty Why does the coronavirus spread so easily between people? PDF version An image of the new coronavirus taken with an electron microscope.Credit: U.S. National Institutes of Health/AP/Shutterstock As the number of coronavirus infections approaches 100,000 people worldwide, researchers are racing to understand what makes it spread so easily. A handful of genetic and structural analyses have identified a key feature of the virus — a protein on its surface — that might explain why it infects human cells so readily. Other groups are investigating the doorway through which the new coronavirus enters human tissues — a receptor on cell membranes. Both the cell receptor and the virus protein offer potential targets for drugs to block the pathogen, but researchers say it is too early to be sure. “Understanding transmission of the virus is key to its containment and future prevention,” says David Veesler, a structural virologist at the University of Washington in Seattle, who posted his team’s findings about the virus protein on the biomedical preprint server bioRxiv on 20 February1. The new virus spreads much more readily than the one that caused severe acute respiratory syndrome, or SARS (also a coronavirus), and has infected more than ten times the number of people who contracted SARS. Spiky invader To infect a cell, coronaviruses use a ‘spike’ protein that binds to the cell membrane, a process that's activated by specific cell enzymes. Genomic analyses of the new coronavirus have revealed that its spike protein differs from those of close relatives, and suggest that the protein has a site on it which is activated by a host-cell enzyme called furin. This is significant because furin is found in lots of human tissues, including the lungs, liver and small intestines, which means that the virus has the potential to attack multiple organs, says Li Hua, a structural biologist at Huazhong University of Science and Technology in Wuhan, China, where the outbreak began. The finding could explain some of the symptoms observed in people with the coronavirus, such as liver failure, says Li, who co-authored a genetic analysis of the virus that was posted on the ChinaXiv preprint server on 23 February2. SARS and other coronaviruses in the same genus as the new virus don't have furin activation sites, he says. https://www.nature.com/articles/d41586-020-00660-x More covid19 can get into. Furin, ACE2 and CD147.

Agree with you Gal. Made a mistake earlier on a part posting if worked on a bat in a lab (possibly). Just reacting to CD147 receptor. After researching more scares me. Even legit people like medcram talking about it now. Posted a youtube video. https://www.medcram.com/ Physicians Over 25,000 physicians utilize MedCram to learn and review concepts with lasting clarity. Enjoy an ideal balance of relevant pathophysiology, clinical pearls, and exam prep (USMLE, Boards). A few of the most popular courses for physicians: There youtube video today Good video but I think maybe too early to say to know on CD147. Infects lots of cells among other things. But people going to study it more and more. Know it better I think here forward. Still little early in the process to know. But anyway's glad what President Trump did today did to WHO. Sorry going off topic a little bit.

Really think wait until end of April and see how thing's go before then for all the states. Go from there.

Researching cd147. Lots people saying this virus can get into ACE2 and CD147 . Red blood cells (maybe immune system cells with 147?) and many more cells. Little evidence on it right now going to try to study deeper into it. The interesting part is again chloroquine or hydrochloroquine works on CD 147 treat malaria. Role in malaria[edit] It has recently (November 2011) been found that basigin is a receptor that is essential to erythrocyte invasion by most strains of Plasmodium falciparum, the most virulent species of the plasmodium parasites that cause human malaria. It is hoped that by developing antibodies to the parasite ligand for Basigin, Rh5, a better vaccine for malaria might be found.[7] Basigin is bound by the PfRh5 protein on the surface of the malaria parasite. Role in SARS-CoV-2 infection (COVID-19)[edit] The host-cell-expressed basigin (CD147) may bind spike protein of SARS-CoV-2 and possibly be involved in host cell invasion.[17] Consequently, meplazumab, a humanized anti-CD147 antibody has been tested in patients with SARS-CoV-2 pneumonia.[18] The exact role and significance of basigin in COVID-19 is still unknown (as of March 2020). https://en.wikipedia.org/wiki/Basigin No way if this is from a bat. Looking more lab made. Not saying true but a possibility. Needs more research on CD147. I think sometime scientists going to find this out as well.

nevermind wrong post

Very sad RIP

The guy answered my question would ask (if I was there) President Trump if a second wave. Answered perfectly.

The media making this stupid. President Trump making this better.

That is one of the worst questions to ask lol. Nothing really on covid19 with that question.