First, and furthermost; the best tip I can give you is make sure your Punt, and Kick returner is LEE EVANS. I usually run 1 back once per game, he is sooo fast. I have yet to run one back with mclovin, or parrish. I know it seems weird but trust me!
Also game doesn't manually order the depth chart so put in to start : Maybin, Levitre, Wood, also would recommend putting in scott in saftey with donte.
On defense I hardly ever use 4-3 because we give up the long runs to the sides, and ellison is horrible so I mainly use the nickle.
Will post more later, anyone else have any good tips for using the bills?