This is an interesting idea, Belichick thought that would be the counter to defenses adjusting to stop the pass with nickel, by running 12 personnel with guys who can also run routes to bring an increased threat of run and pass. Fortunately Jonnu took a giant dump and Henry hasn't been able to take all the slack.
A high pick on interior OL, a heavy RB, and an ability to run 10 as much as 12 is kind of the offensive Janus to Belly's defensive multiple-ness. The Bills could be set to do that with a mere few additions via the draft or FA.