Bob in Mich
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Posts posted by Bob in Mich
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This topic seemed like a good one after yesterday's Bills-Bucs game. It discusses both anxiety and depression. I know, I know, it is only the preseason
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
Published 5-Dec-2012
http://www.ncbi.nlm....les/PMC3481531/
From the Report's Abstract Section
Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ9-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties.
It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis.
GW Pharmaceuticals is also investigating the use of cannabinoids for mental disorders.
http://gwpharm.com/p...conditions.aspx
On the basis of laboratory evidence, anxiety and depression are promising targets for cannabinoid medicines and there are some preliminary human data in support of thisi,ii. Emerging evidence suggests that the cannabinoid, cannabidiol (CBD), possibly in combination with other cannabinoids, may have potential utility in schizophrenia not only as an anti-psychotic, but also in the alleviation of the metabolic and inflammatory abnormalities associated with the disease.
CB1 antagonists may have a role in relapse-prevention in the treatment of addictioniii. Other possible targets for the future based on human anecdote or limited laboratory research include bipolar affective disorder, post-traumatic stress syndrome, eating disorders, and insomnia
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That is a sad story. It certainly sounds like the guy snapped.
I think trying to tie the murder to the ingestion of THC is a very big stretch, however. Prohibitionists are grasping at any straw these days.
For argument's sake, let's say the THC caused this man to kill his wife. If that is the case, why has no one else that we know of been driven to kill? Tens, if not hundreds of thousands, or maybe even millions of people have ingested THC infused products.
Might it be that this guy had some mental problems and that day he lost it?
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http://www.caintv.co...legalization-ha
1. The majority of DUI drug arrests involve marijuana and 25 to 40 percent were marijuana alone.2. In 2012, 10.47 percent of Colorado youth ages 12 to 17 were considered current marijuana users compared to 7.55 percent nationally. Colorado ranked fourth in the nation, and was 39 percent higher than the national average.3. Drug-related student suspensions/expulsions increased 32 percent from school years 2008-09 through 2012-13, the vast majority were for marijuana violations.4. In 2012, 26.81 percent of college age students were considered current marijuana users compared to 18.89 percent nationally, which ranks Colorado third in the nation and 42 percent above the national average.5. In 2013, 48.4 percent of Denver adult arrestees tested positive for marijuana, which is a 16 percent increase from 2008.6. From 2011 through 2013 there was a 57 percent increase in marijuana-related emergency room visits.7. Hospitalizations related to marijuana has increased 82 percent since 2008.Legal marijuana means more people smoking marijuana (especially kids), which means more problems in the realms of crime, public health, driving hazards, school discipline. One of the most idiotic arguments in favor of pot legalization is that it "takes the crime out of it." It does no such thing. It creates so much undisciplined behavior on the part of people who are not the sharpest tools in the drawer to begin with, the result is far more overall criminal behavior, even if possession of pot itself is not something to be prosecuted.
About that: If legalization is not supposed to lead to a rise in teens smoking pot, then how do you explain drug-related suspensions and expulsions up 32 percent in four years? Because it obviously does lead to more teens doing it. There is no way it could be otherwise. Any time you remove the sanction from a behavior, you get more of that behavior. More adults able to acquire pot legally means more people for teens to get it from. Come on. Don't be a moron. Use your brain for once, if you still have any of it left.
And stop with the idiocy about how "the war on drugs failed" because it didn't result in fewer people doing drugs. Name one other criminal law that's judged in that way. Rapists are still at it. Anti-rape laws have failed!
Are you really that stupid? The purpose of a criminal law is to impose a sanction on those who commit the crime, and to protect society from those same people.
If more people are using drugs, the law hasn't failed. Those people have failed. And now we're seeing some of the social costs of changing the law to accommodate their failures.
[security, I moved your post to this thread as I would like to keep the 'Cannabis and Disease' thread focused on health issues.]
The logic from that article is even worse than the terribly flawed study that it is based upon. The author decries legal marijuana and then proceeds to cite statistics from a period prior to legalization.
Here is an article talking about the effects since legalization in Colorado
http://wallstcheatsh...ppears-so.html/
Is Legal Marijuana Making the Streets Safer? It Appears So
From the article
Well, a year and a half after legalization was passed in two states, and now nearly nine months after Colorado initiated legal sales of cannabis to the general public, it appears that legalization has indeed made the streets safer. In fact, marijuana use among teenagers has actually dropped in Colorado, much to the surprise of everyone.
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The link takes me to an article about gun shootings in Chicago. what is your point?
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He has none. In fact, the stats bear out the opposite. As an example, the several colleges that permit open carry, rather than opperate as gun free zones, have the lowest rates of crime in the country.
So, you really feel that if the entire population carried guns at all times, we would all be safer? Are you sure that you are considering shootings of jealously, rage, betrayal, mental illness, drunkeness, etc?.
Consider the recent nights in Missouri for a moment. I have no link or stats to back this up but I feel there would be more dead if every person there was armed over this last week. You don't?
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Cannabinoids as therapeutic agents in cancer: current status and future implications
Published: July 17, 2014
http://www.impactjou...233&path[]=3664
From the report
Conclusions and future directions
Cannabinoids exert a direct anti-proliferative effect on tumors of different origin. They have been shown to be anti-migratory and anti-invasive and inhibit MMPs which in turn degrade the extra-cellular matrix (ECM), thus affecting metastasis of cancer to the distant organs. Also, cannabinoids modulate other major processes in our body like energy metabolism, inflammation, etc.
These data are derived not only from cell culture systems but also from more complex and clinically relevant animal models. Before cannabinoids could be used in clinical trials, there is need to explore more knowledge on several issues such as anti-tumorigenic and anti-metastatic mechanisms as well as which type of cancer patient populations would be more responsive for cannabinoid based therapies.
Data presented in this review suggest that cannabinoids derived from different sources regulate differently signaling pathways, modulate different tumor cell types and host physiological system. It is important to understand which of the cannabinoid receptors are expressed and activated in different tumors as each receptor follows a different signaling mechanism
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And, from the GW Pharmaceutical website http://gwpharm.com/oncology.aspx
Info: Cannabinoids in Oncology
The possibility that cannabinoids, including endocannabinoids, may treat cancer is supported by an ever increasing body of available evidence. In simple terms, cancer occurs because cells become immortalised; they fail to heed customary signals to turn off growth. A normal function of remodelling in the body requires that cells die on cue. This is called apoptosis, or programmed cell death and this process fails to proceed normally after malignant transformation. As will be discussed in greater detail below, THC, CBD, and perhaps other phytocannabinoids promote the re-emergence of apoptosis so that certain cancer cell types will in fact heed the signals, stop dividing, and die
This report from the National Cancer Institute is interesting too
http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4#Section_26
From the report
Cannabinoids may cause anti-tumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents. Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death.
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Cannabis finds its way into treatment of Crohn’s disease
http://www.ncbi.nlm....pubmed/24356243
From the report
In ancient medicine, Cannabis has been widely used to cure disturbances and inflammation of the bowel. A recent clinical study now shows that the medicinal plant Cannabis sativa has kept its expectancies proving to be highly efficient in cases of inflammatory bowel diseases (IBD).
In a prospective placebo-controled study, Naftali and coworkers (Clin. Gastroenterol. Hepatol. 11,1276-1280. e1., 2013) have shown what has been largely anticipated from anectodal reports, that Cannabis produces significant clinical benefits in patients with Crohn’s disease. The mechanisms involved are not clear yet but most likely include peripheral actions on cannabinoid receptors 1 and 2, and may also include central actions.
There is also this report that I mentioned in an earlier thread
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This research report is pretty technical but it gives an intro to this topic. Published online Mar 5, 2014
Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
http://www.ncbi.nlm....les/PMC3942876/
From the report
CONCLUSIONS AND THERAPEUTIC IMPLICATIONS
Considering the numerous complex pathological mechanisms involved in the progression of AD, treatments targeting a single causal or modifying factor offer limited benefit. Cannabinoids, however, exhibit pleiotropic activity, targeting in parallel several processes that play key roles in AD, including Aβ and tau aberrant processing, neuroinflammation, excitotoxicity, mitochondrial dysfunction, and oxidative stress. Cannabinoids improve behavioral disturbances, as well.
Then, because of these widespread properties of cannabinoid compounds, targeting the ECS could represent a unique and reliable opportunity to advance toward an effective therapy against the AD. Moreover, cannabinoids might represent a safe low-cost therapy, with their natural origin and low side effects profile. From our point of view, the success of cannabinoid-based therapy in AD could be increased taking into account two important aspects: (i) the use of a combination of compounds that cover the whole spectrum of therapeutic properties described for cannabinoids, i.e., combination of CB1 and CB2 receptors agonists plus CBD, which presents interesting neuroprotective properties spite of its mechanism of action remaining poorly understood, and (ii) the early initiation of the treatment in the neurodegenerative process, which ensures the integrity of the ECS target components and increases the possibility of curbing the exponential degenerative progression toward dementia.
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Fantastic!!
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Why does it not have a cupholder yet it has that fireplace log holder attachment?
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Wasn't part of the plan to bankrupt the US? It seems that all our enemies have to do is to keep creating crises in multiple locations around the globe.
As long as we continue to believe we should take the lead in solving all of them, we will be broke soon enough. It costs X dollars to create a problem and 10,000X to clean it up and defend against it in the future.
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Marijuana Treatment for Parkinson's Highlighted in Robin Williams's Death
From the article
Researchers reported that smoked administration of the drug created "significant" improvement in the symptoms suffered by research subjects including dramatically decreased rigidity, tremor and pain and increased ability to properly rest. Patients also reported that the effects lasted for as long as three hours. No adverse effects were reported.
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But Buffalo and Detroit are close to each other and have the rivalry in hockey so playing them is natural.
If you asked Detroit hockey fans to order their rivals, most would never get to mentioning the Sabres.
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Doesnt every team face the same opponent the 4th preseason game?
I think you are correct, Cap'n. I had never noticed that before.
EDIT: I guess not always though as there are some differences year to year now that I have looked closer.
http://www.nfl.com/scores/2012/PRE4
http://www.nfl.com/scores/2013/PRE4
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Preseason games should be against teams that are the closest, it's practice.
Do teams fly in for those games or take the bus?
If they fly in, there are about a dozen teams that are similarly close, give or take a half hour.
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A close opponent is nice. I agree too that the final preseason game is the worst one.
I still think a variety of opponents would be better than the same ones year in and year out.
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William Clay Ford, the Lions former owner passed in March 2014 so if that series was based on his connection with Ralph, it will likely pass away too.
I wondered how far out they 'book' preseason games. After whatever is booked expires, they will probably end that series, imo.
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This article, though from October 2013 does a pretty good job of summarizing information related to cannabis and disease. It sort of updates the 2006 study on therapeutic benefits, though it is much less technical.
The Therapeutic Benefits Of Cannabis, According To Science
http://www.medicalja...ing-to-science/
Also, the 'Classroom' area of the MedicalJane's website has all sorts of information on various diseases. Check it out when you get a chance. It is very informative.
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The final installment in the NY Times series
http://www.nytimes.com/2014/08/05/opinion/high-time-rules-for-the-marijuana-market.html?op-nav
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The NY Times series on cannabis continues
The Great Colorado Weed Experiment
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http://www.cnn.com/2....html?hpt=hp_t1
Choke hold by cop killed NY man, medical examiner says
(CNN) -- The New York City medical examiner's office Friday confirmed what demonstrators had been saying for weeks: A police officer's choke hold on a man being arrested for selling loose cigarettes killed him. The death has been ruled a homicide.
Eric Garner, 43, died July 17 after being confronted by policeon Staten Island for allegedly selling cigarettes illegally.
During the encounter, Garner raised both hands in the air and told the officers not to touch him. Seconds later, a video shows an officer behind him grab the 350-pound man in a choke hold and pull him to the sidewalk, rolling him onto his stomach. (continued at link)
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NY Times article on health concerns of cannabis
http://www.nytimes.com/2014/07/31/opinion/what-science-says-about-marijuana.html?op-nav
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The next NY Times article in their series is out.
What Science Says About Marijuana
http://www.nytimes.com/2014/07/31/opinion/what-science-says-about-marijuana.html?op-nav
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He was supposed to be suspended for our playoff game last year but, well you know.
Marijuna related health problems on the rise in US
in Politics, Polls, and Pundits
Posted
A new study suggests that a few strong whiffs of black pepper can calm anxiety brought on by marijuana
How Black Pepper relieves Cannabis Anxiety
By Owen Smith — 17 Jul, 2014
http://cannabisdiges...nnabis-anxiety/
From the article
While working at the Victoria Cannabis Buyers Club I was able to teach some of the members about Black Pepper. While benefiting from the medicinal effects of THC, these patients suffered from bouts with anxiety while medicating.
Most patients who have tried this simply took a few sniffs of the black pepper to receive an almost immediate effect. Others have reported that after chewing on pepper corns they felt relief within an hour...