Why am I so nervous about this one? Is the because it feels like everything is pointing to a win? Josh and the Bills' December records, the Niners injury issues, Milano back, the weather, being played at Highmark... But the NFL doesn't work like that. No sport does. And my biggest fear is if the Niners get the running backs working as a unit rather than over-using McCaffrey. The Bills run D is not the best.
Get the win, no injuries, and move on.