I feel like the Bills offense has played well at times, and that is when they are allowed to take chances and "go for it". Once they had gotten the lead in the Giants & Bengals games, conservatism has limited their ability to continue to push the ball down the field. Call it a lack of focus, lack of killer instinct - whatever it is has allowed teams to hang around.
With the Pats game, I think you'll see that sustained focus on O because they know the Patriots will get their points. They won't go John Harbaugh Riverboat Ron crazy (this is McD you know), but the offense will need to be consistent. I think this offensive consistency will be the big surprise of the game. Lots of 8-10 play drives, maybe not all ending in Tds, but productive none the less. Hopefully it will be enough to pull out a win.