Buffalo has been losing its tax base for 3 decades. Any new business would be helpful. And some businesses more helpful than others. The workforce in Buffalo is not skilled enough for most modern businesses. There is a lack of technically skilled people and a lack of creative people. Information technology firms, marketing or advertising firms, biogenetic firms and financial institutions would need to import a workforce. But, I couldn't imagine anyone wanting to move to Buffalo for a job. There are no amenities in the city....other than bars; housing is not attractive either. There are still race wars going on. And whole sections of the city are crime ridden, in particular the entire east side of Buffalo.
If the Senecas are allowed to open and run the casino, I doubt that there will be tax dollars generated from it. Generally, tribes do not have to pay taxes because of treaties. So, the best you can expect from the casino would be unskilled work positions and service industry postions. These types of jobs generally do not improve an economy.
The money that is pulled out by the casino, is money not available for local businesses, taxes, savings, investments and entrepreneurial endeavors. So, the area will continue to be dummied down and you'll see more politicians like Giambra who embodies these problems.