I live in Northeast (NE) Portland. I have continually lived in Portland for the last 15 years and, on and off, for the last 20 years. Like most cities, Portland does have a few sketchy spots, but those are mostly scattered around town. Generally we tend to enjoy a really high quality of life here. Lots of public transit, biking is easy (by US standards) and the city is littered with local neighborhood centers where there are shops, restaurants, and other local businesses. In all seriousness, I often leave my house unlocked for hours at a time while out and about.
The city has 6 main, and distinct, parts. As I said, I live in NE Portland which is very residential. There is also a SE Portland that is also very residential. The East side in general tends to follow a classic city grid pattern and is relatively flat which makes it very walkable. There is also a North Portland, which is also residential but a little bit off the beaten path because it takes bit of work to access. The Willamette river divides the east side from the west side. Great walkable and bike-able bridges cross the river one of which is, in fact, a pedestrian, bus, light rail, bike only bridge. On the west said, there is NW Portland characterized by the Pearl District which has taller apartment buildings and condos and some great neighborhood hang out spots and parks (Portland is loaded with public parks). If you head South from "the Pearl" (as it is known here) you start to get into downtown. Our downtown has seen better days. It was thriving up until Covid but the combination of remote work and the 2020 protests did take a toll on downtown. However, downtown is better today than it was a year or two ago and there are still some classic sites to visit in downtown (Powells Books, and the Saturday Market as some examples). Once you head South out of downtown you get in SW Portland. The SW waterfront is spectacularly. It is where you will find the tram that takes you up into Oregon Health and Science University (OHSU) up going into the west hills. The SW waterfront has tall, Vancouver BC like towers and parks and neighborhood appeal on the ground level of the area. Further back in SW you start to go into the west hills where the neighborhoods are less obviously walkable but still with their own neighborhood centers (like Multnomah Village) and, of course, great parks.
One last thing, this is a great, great, food city. Truly an embarrassment of riches.