Having some time to think it over, I'm slightly more optimistic about this season. (edit: compared to immediately after the game)
So many "what ifs", kind of like the Houston playoff game, where if one thing goes right they end up winning.
They could absolutely beat the Bucs or Patriots or both. Every game remaining game is 50/50 to me.
That being said, half of those "what ifs" are deliberate decisions by this head coach and/or OC.
It's hard enough to win a Super Bowl, you have to beat the other teams, the injury bug, sometimes the refs, and the Bills with McDermott also have to overcome his in-game decisions.
So although I still think we have a chance this season, I think it's the same small chance they'll have going forward with McDermott at the helm.