The 3 big almost touchdown plays (Cook, Coleman and Hawes) where the Bills ended up scoring a TD anyway - that took necessary time that impacted the end of the game. If the game had been tied and add'l time, Bills might have gone for a TD. So many things in the game determined how it ended.
But, Bills defense is still very suspect. You can't really fix just getting beat on the line of scrimmage.
You can't just expect to get turnovers and your QB to get 250 yards in the 4th qtr. to win games.