For the hell of it, here's all the seasons we started 2-0:
1964: Finished 12-2, won AFL championship
1965: Finished 10-3-1, won AFL championship
1975: Finished 8-6, no playoffs
1980: Finished 11-5, lost divisional game
1981: Finished 10-6, lost divisional game
1982: Finished 4-5, no playoffs
1988: Finished 12-4, lost conference championship
1991: Finished 13-3, lost Super Bowl
1992: Finished 11-5, lost Super Bowl
1993: Finished 12-4, lost Super Bowl
1996: Finished 10-6, lost Wild Card game
2000: Finished 8-8, no playoffs
2003: Finished 6-10, no playoffs
2008: ???
So, this is the 14th time the Bills have started 2-0. Of the previous 13, the Bills made it to the playoffs 9 times and made it to the championship 5 times. Four years they missed the playoffs, one of which was in the strike-shortened season.