Looking at this game independent of schedule, it would be hard to understand how a win would be more 'impressive' than say the Falcons game. BUT, I think the OP's point is to look at this through the lense of the sequence of the schedule. I'd have to agree that this win would tell us something *different* about what this Bills team is made of (compared to the Atlanta game). Favorite quote from McD after the game was about how the guys shouldn't get too ahead of themselves, and not focus on the 'high' of the win over Atlanta. Instead they should become addicted to the process it took to achieve that win.
The opponent will change each week, but being motivated to follow those steps the team agrees will lead them to the best chance to win is the important part. NOW, with a few players banged up, how will they adjust, improve on areas, and use the team/members they have available to get a "W" at Cincy. That will definitely tell us something *different* than the win over the Falcons, and in a way, after seeing the years of (dis-) organizational futility, that may be a more impressive win.
Two things I'd hope to see/be impressed about this game:
-If Dareus is healthy enough, does he have a break out day? SOMEONE should have abig day pressuring Dalton (Stats make it look like Cincy's O line hasn't been good -- but I haven't watched their games other than the Ravens game)
-Can Buffalo control the line for the run game and get Shady on track? (Cincy's D gives up 3.9 yards / run play, same stat as Buffalo's defense, but Buffalo has forced 2 turnovers vs. 0 from Cincy)