Over the past few seasons teams have been developing the approach to neutralizing the mobile quarterback.  The Bills were an early adopter, and I think they are continuing the development of the technique.    The basic approach is that the pass rushers have to maintain lane discipline, so that none of the usual escape routes are easily available to the QB.  Murray beat the Bills on the Hail Mary because someone bit instead of holding the edge.  The Bills used the technique beautifully