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NFL Week 2 odds, over/under: Bills open as big underdog to Panthers

'Despite a 21-12 win over the Jets in Sean McDermott's first game as head coach, the Bills are facing an uphill battle against the Panthers, who beat the 49ers 23-3 on the road this week. Cam Newton didn't have his best game, but the Panthers' defense, which was previously coached by McDermott, appears to be a formidable unit once again. Much will be made about McDermott's return to Carolina, and those on the outside don't expect much from his team.'

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