‘The Bills (6-5) have little margin left for error if they intend to make the playoffs, and just as they did a week ago in Kansas City, need to be focused and prepared to take care of business against a less-than-formidable opponent in the 49ers (3-8). Buffalo can take its pick in attacking San Francisco weaknesses: Pressure young QB Shaun Hill (team has allowed 40 sacks). Fly to the ball (49ers have 27 turnovers). Have Trent Edwards throw (San Francisco’s 29th-ranked secondary allows 244 yards per game). The running back duel between Marshawn Lynch and Frank Gore on what will be a cold, maybe slick weather day will go a long ways toward determining the outcome. Basically, the Bills should have no problem winning at home against a team that has traveled across the country, not with renewed playoff hopes after last week’s 54-point explosion against the Chiefs. They shouldn’t take the 49ers too lightly, though. San Francisco leads the NFL with 52 plays of 20 yards or more (running and passing), so it has the capability of punching back.’