I expect John Brown and Beasley to have pretty good games especially as long as the Oline allows Josh time to do his thing. Also expect Tre White to give Hopkins a hard time which means if Fuller is a go for the Texans, other CB's will have to step up their game big time.
I envision Watson throwing an INT, hopefully more than 1. Have a feeling this is going to be a fairly close game and hopefully the Bills will make the least mistakes and come out of there with a victory.