‘Key matchup – Rams offensive line vs. Bills defensive line. Keep QB Matthew Stafford upright, and open up holes for RB Kyren Williams. It’s a pretty simple formula for the Rams, and they executed it well in New Orleans, letting Williams rush for 104 yards while Stafford was only sacked twice. Buffalo has two disruptive ends in Gregory Rousseau (6 1/2 sacks, 15 tackles for loss) and A.J. Epenesa (5 sacks), so keeping them in check will be a challenge. The Bills are also proving to be sturdier in stopping the run in recent weeks, though there was statistical regression last week with San Francisco reduced to keeping the ball on the ground in heavy snowfall.’