‘The pick: Under 45.5. If the Saints are going to be without this many key players, it’s hard to imagine that Trevor Siemian will be able to put many points on the board, especially against this Buffalo defense that is still No. 1 in the NFL in DVOA entering Week 12. Even with the Bills averaging 31 points per game on the road this season, it’s hard banking on the Saints to carry out their end of the bargain to have this go over.’