‘KEY MATCHUP: Titans RB Derrick Henry vs. Bills DT Star Lotulelei. Henry was limited to 57 yards on 19 carries in the Titans’ 42-16 win over the Bills last year, but most notably stiff-armed his way to score two touchdowns. Buffalo’s run defense was inconsistent all last year with Lotulelei opting out for COVID-19 reasons. He’s back and represents a big reason the Bills have limited opponents to 392 yards rushing and one TD. Henry has run for at least 113 yards in four straight games.’