Talley was selected by the Bills in the second round of the 1983 draft out of West Virginia. He played 12 seasons with Buffalo and is one of just 10 individuals to play at least a dozen seasons with the Bills. A long-time fixture on the Bills defense of the late 80s and early 90s, his 188 regular season games played rank as the fifth-most in team history while his 1,137 tackles rank second and 38.5 sacks rank fifth.