After blowing up their offensive line during the bye week, the 3-5 Bills managed to beat Green Bay despite just 184 yards of total offense, but didn’t have nearly as much success the following Sunday in Indy. The Colts’ pass rush pressured J. P. Losman all afternoon, sacking him four times on just 16 passing attempts, and the Buffalo offense never did find the end zone – Terrence McGee scored their only touchdown on a 68-yard fumble recovery to tie the game at 10 just before halftime.
Rian Lindell, who had already connected on three previous field goal attempts to keep the Bills in the game, lined up for a 41-yarder to put them into the lead with just over six minutes remaining. But the kick sailed wide right, and the Colts ran out the clock to improve to 9-0.
Buffalo (4-7) held an improbable 14-3 lead early in the fourth quarter, but the Colts mounted two late touchdown drives to cap the comeback victory. Edgerrin James powered across for the go-ahead score on fourth-and-goal from inside the 1 with just 1:38 on the clock, and the Bills’ last-minute comeback attempt ended with a Drew Bledsoe interception at midfield.