The Bills found the win column for the first time in a month against the hapless Chiefs. Leodis McKelvin made his first NFL interception count, returning it for a 64-yard touchdown and a 20-14 second-quarter lead, and the Bills poured on the points from there. Trent Edwards had one of the best games of his young career, going 24-for-32 for 273 yards and two touchdowns, good for a career-best 121.0 passer rating.
The Bills improved to 6-5, but would win just one more game the rest of the season. Kansas City fell to 1-10 with the loss, on the way to a 2-14 finish and the No. 3 overall pick in the 2009 draft.